Severe anxiety and panic disorder: Psychiatrist Michael Yasinski MD discusses his unieque expertise in using MAO-l’s to successful treat the most severe cases

Treatment resistant anxiety and panic is one of the most common problems I see and I have seen a disappointing trend in the psychiatric community be unwilling to utilize potent tools in the fight against treatment resistant anxiety for a variety of reasons. One of the most potent tools to treat severe anxiety or panic is utilizing an MAO-I (Monoamine oxidase inhibitor). MAO A and MAO B are enzymes in our brain which metabolize neurotransmitters involved in depression. MAO A helps break down dopamine, norepinephrine and serotonin and MAO B breaks down dopamine.

In addition, MAO-I drugs act to modify other circuits, gene regulation and receptor expression involved in treatment resistant anxiety disorders which goes above and beyond its effect on the 3 well-known neurotransmitters serotonin, norepinephrine and dopamine. I have utilized MAO-I’s extensively over the past 3 years and have seen tremendous results in people who have had no response or minimal response to other typical antidepressants.

The MAO-I that I find most effective is Nardil for severe treatment resistant anxiety and panic. Nardil is inhibits both MAO-A and MAO-B which provides a potent ant-depressant response in the brain. Nardil is particularly useful for panic and anxiety disorders. While I have used it for depression, I find Nardil has a potent effect on patients dealing with treatment resistant panic and anxiety. Parnate, another MAO-I can also be effective, however with my experience, that is a more potent tool for the depression spectrum.

I have treated dozens of patients who had minimal response to traditional medications such as SSRI’s and other anti-depressants traditionally used for anxiety and panic. I often use Tricyclic antidepressants as well which are another potent tool, however even in some people who do not response to those, MAO-I offers a robust response in many of them.

The main concern with many patients and physicians who are not experienced in using the medication is some dietary restrictions. From years of prescribing these medications for treatment resistant anxiety and depression, I have not seen a single problem when people follow some basic guidelines. Here is a link from mayo clinic on the MAO-I diet

If you are struggling with treatment resistant anxiety or panic and want someone with experience in the most potent tools available please call me and I am happy to discuss the many options.